Article
Allelic variation in the mouse Tap-1 and Tap-2 transporter genes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1997
Marusina K, Iyer M, Monaco J J
Abstract excerpt
The TAP1 and TAP2 proteins form a heterodimer that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Extensive allelic polymorphism of the rat TAP transporter has been shown to affect the repertoire of peptides presented by MHC class I molecules. Structural polymorp...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Amino Acid Sequence
- Animals
- Histocompatibility Antigens Class I
- Humans
- Mice
- Molecular Sequence Data
- Polymorphism, Genetic
- Rats
- Sequence Alignment
- Sequence Analysis