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Article

Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin.

Journal of cell science - 1 Nov 2017

Gao Juan, Huang Ming, Lai Jingjing, Mao Kaijun, Sun Peisen, Cao Zhongyuan, Hu Youpei, Zhang Yingying, Schulte Marie L, Jin Chaozhi, Wang Jian, White Gilbert C, Xu Zhen, Ma Yan-Qing

Abstract excerpt

Kindlins play an important role in supporting integrin activation by cooperating with talin; however, the mechanistic details remain unclear. Here, we show that kindlins interacted directly with paxillin and that this interaction could support integrin αIIbβ3 activation. An exposed loop in the N-terminal F0 subdomain of kindlins was involved in mediating the interaction. Disruption of kindlin binding to paxillin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28954813
DOI: 10.1242/jcs.205641
PMCID: PMC6040092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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