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Article

Nascent DNA synthesis during homologous recombination is synergistically promoted by the rad51 recombinase and DNA homology.

Genetics - 1 May 2014

Mundia Maureen M, Desai Vatsal, Magwood Alissa C, Baker Mark D

Abstract excerpt

In this study, we exploited a plasmid-based assay that detects the new DNA synthesis (3' extension) that accompanies Rad51-mediated homology searching and strand invasion steps of homologous recombination to investigate the interplay between Rad51 concentration and homology length. Mouse hybridoma cells that express endogenous levels of Rad51 display an approximate linear increase in the frequency of 3' extension...

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Share to BRCA2 Protein
Share to DNA Damage
Share to Homologous Recombination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Multimerization

Share to Protein Structure, Quaternary

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Share to Rad51 Recombinase

Share to Sequence Homology, Nucleic Acid

Source

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Identifiers

PMID: 24583581
DOI: 10.1534/genetics.114.161455
PMCID: PMC4012472

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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