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Article

Genetic steps of mammalian homologous repair with distinct mutagenic consequences.

Molecular and cellular biology - 1 Nov 2004

Stark Jeremy M, Pierce Andrew J, Oh Jin, Pastink Albert, Jasin Maria

Abstract excerpt

Repair of chromosomal breaks is essential for cellular viability, but misrepair generates mutations and gross chromosomal rearrangements. We investigated the interrelationship between two homologous-repair pathways, i.e., mutagenic single-strand annealing (SSA) and precise homology-directed repair (HDR). For this, we analyzed the efficiency of repair in mammalian cells in which double-strand break (DSB) repair...

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Source

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Identifiers

PMID: 15485900
DOI: 10.1128/MCB.24.21.9305-9316.2004
PMCID: PMC522275

Genes

BARD1
BRCA1
RAD51
BRCA2
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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