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Article

An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility.

American journal of human genetics - 6 Mar 2014

Breyer Joan P, Dorset Daniel C, Clark Travis A, Bradley Kevin M, Wahlfors Tiina A, McReynolds Kate M, Maynard William H, Chang Sam S, Cookson Michael S, Smith Joseph A, Schleutker Johanna, Dupont William D, Smith Jeffrey R

Abstract excerpt

Genetic association studies of prostate and other cancers have identified a major risk locus at chromosome 8q24. Several independent risk variants at this locus alter transcriptional regulatory elements, but an affected gene and mechanism for cancer predisposition have remained elusive. The retrogene POU5F1B within the locus has a preserved open reading frame encoding a homolog of the master embryonic stem cell...

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Identifiers

PMID: 24581739
DOI: 10.1016/j.ajhg.2014.01.019
PMCID: PMC3951923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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