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BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1

28 May 2019

Abstract excerpt

BACKGROUND: Cancer stem-like traits contribute to prostate cancer (PCa) progression and metastasis. Deciphering the novel molecular mechanisms underlying stem-like traits may provide important insight for developing novel therapeutics. METHODS: Immunohistochemistry and immunofluorescence assays in prostatic tissues; gain- and loss-of-function analyses using ectopic overexpression and shRNAs in PCa cell lines;...

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PMID: 31138311
DOI: 10.1186/s13046-019-1222-z

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