A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.

doi:10.1158/0008-5472.CAN-04-4249

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.

Cancer research - 15 Feb 2005

Narla Goutham, Difeo Analisa, Reeves Helen L, Schaid Daniel J, Hirshfeld Jennifer, Hod Eldad, Katz Amanda, Isaacs William B, Hebbring Scott, Komiya Akira, McDonnell Shannon K, Wiley Kathleen E, Jacobsen Steven J, Isaacs Sarah D, Walsh Patrick C, Zheng S Lilly, Chang Bao-Li, Friedrichsen Danielle M, Stanford Janet L, Ostrander Elaine A, Chinnaiyan Arul M, Rubin Mark A, Xu Jianfeng, Thibodeau Stephen N, Friedman Scott L, Martignetti John A

Abstract excerpt

Prostate cancer is a leading and increasingly prevalent cause of cancer death in men. Whereas family history of disease is one of the strongest prostate cancer risk factors and suggests a hereditary component, the predisposing genetic factors remain unknown. We first showed that KLF6 is a tumor s...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Growth Processes

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Genes, Tumor Suppressor

Share to Kruppel-Like Transcription Factors

Share to Phosphoproteins

Share to RNA-Binding Proteins

Share to Serine-Arginine Splicing Factors

Source

Open in PubMed

Identifiers

PMID: 15735005
DOI: 10.1158/0008-5472.CAN-04-4249

Genes

KLF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15735005-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.PMID 15735005Read ↗

KLF6, a candidate tumor suppressor gene mutated in prostate cancer.Semantic proximity Read ↗

Deletion, mutation, and loss of expression of KLF6 in human prostate cancer.Semantic proximity Read ↗

Characterization of the prostate cancer susceptibility gene KLF6 in human and mouse prostate cancers.Semantic proximity Read ↗

KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.Semantic proximity Read ↗

The splicing factor SRSF6 regulates AR activity and represents a potential therapeutic target in prostate cancerSemantic proximity Read ↗

Association between Krüppel like factor 6 intervening sequence 1-27 G > A and cancer susceptibility: A meta-analysis.Semantic proximity Read ↗

Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas.Semantic proximity Read ↗

Kruppel-like factor 6 germ-line mutations are infrequent in Finnish hereditary prostate cancer.Semantic proximity Read ↗

SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer.Semantic proximity Read ↗

An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility.Semantic proximity Read ↗

Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironmentSemantic proximity Read ↗

RNA splicing and splicing regulator changes in prostate cancer pathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.