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Article

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

Cell death & disease - 27 Feb 2014

Moujalled D M, Cook W D, Murphy J M, Vaux D L

Abstract excerpt

Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 (Drp1), because survival was increased in cells depleted of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24577084
DOI: 10.1038/cddis.2014.18
PMCID: PMC3944236

Genes

RIPK3
MLKL
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Necroptosis induced by RIPK3 requires MLKL but not Drp1.PMID 24577084Read ↗

Necroptosis in development and diseases.Semantic proximity Read ↗

Post-translational control of RIPK3 and MLKL mediated necroptotic cell deathSemantic proximity Read ↗

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis.Semantic proximity Read ↗

The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.Semantic proximity Read ↗

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.Semantic proximity Read ↗

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal HomeostasisSemantic proximity Read ↗

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitisSemantic proximity Read ↗

Necroptosis mediates myofibre death in dystrophin-deficient miceSemantic proximity Read ↗

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.Semantic proximity Read ↗

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.Semantic proximity Read ↗

PRMT5-mediated regulatory arginine methylation of RIPK3Semantic proximity Read ↗

RIPK3 promotes adenovirus type 5 activitySemantic proximity Read ↗

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