Article
Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency.
World journal of gastroenterology - 14 Jan 2014
Ni Ying-Yin, Chen Yan, Lu Shun-Yuan, Sun Bi-Ying, Wang Fang, Wu Xiao-Lin, Dang Su-Ying, Zhang Guo-Hua, Zhang Hong-Xin, Kuang Yin, Fei Jian, Gu Ming-Min, Rong Wei-Fang, Wang Zhu-Gang
Abstract excerpt
AIM: To generate a Gpr128 gene knockout mouse model and to investigate its phenotypes and the biological function of the Gpr128 gene. METHODS: Bacterial artificial chromosome-retrieval methods were used for constructing the targeting vector. Using homologous recombination and microinjection technology, a Gpr128 knockout mouse model on a mixed 129/BL6 background was generated. The mice were genotyped by polymerase...
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