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Article

Similarities and differences in constipation phenotypes between Lep knockout mice and high fat diet-induced obesity mice.

PloS one - 1 Jan 2022

Kim Ji Eun, Seol Ayun, Choi Yun Ju, Lee Su Jin, Jin You Jeong, Roh Yu Jeong, Song Hee Jin, Hong Jin Tae, Hwang Dae Youn

Abstract excerpt

CRISPR-Cas9-mediated leptin (Lep) knockout (KO) mice exhibited prominent phenotypes for constipation, even though they were not compared with other model animals. This study compared the stool excretion, gastrointestinal motility, histological structure, mucin secretion, and enteric nerve function in Lep KO and high fat diet (HFD)-treated mice to determine if there were differences in their phenotypes for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36548335
DOI: 10.1371/journal.pone.0276445
PMCID: PMC9778951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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