Article
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.
European journal of pharmacology - 12 Jan 2007
Kitazawa Takio, Hashiba Kano, Cao Jinshan, Unno Toshihiro, Komori Sei-Ichi, Yamada Masahisa, Wess Jürgen, Taneike Tetsuro
Abstract excerpt
Functional roles of muscarinic acetylcholine receptors in the regulation of mouse stomach motility were examined using mice genetically lacking muscarinic M(2) receptor and/or M(3) receptor and their corresponding wild-type (WT) mice. Single application of carbachol (1 nM-30 microM) produced concentration-dependent contraction in antral and fundus strips from muscarinic M(2) receptor knockout (M(2)R-KO) and M(3)...
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