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Article

Rolling circle amplification for direct detection of rpoB gene mutations in Mycobacterium tuberculosis isolates from clinical specimens.

Journal of clinical microbiology - 1 May 2014

Chen Xiaoyou, Wang Bin, Yang Wen, Kong Fanrong, Li Chuanyou, Sun Zhaogang, Jelfs Peter, Gilbert Gwendolyn L

Abstract excerpt

Rapid and accurate detection of multidrug resistance (MDR) in Mycobacterium tuberculosis is essential to improve treatment outcomes and reduce global transmission but remains a challenge. Rifampin (RIF) resistance is a reliable marker of MDR tuberculosis (TB) since by far the majority of RIF-resistant strains are also isoniazid (INH) resistant. We have developed a rapid, sensitive, and specific method for...

Topics

Antitubercular Agents
Bacterial Proteins
DNA, Bacterial
DNA-Directed RNA Polymerases
Drug Resistance, Multiple, Bacterial
Humans
Isoniazid
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Amplification Techniques

Rifampin

Sensitivity and Specificity

Sputum

Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 24574296
DOI: 10.1128/JCM.00065-14
PMCID: PMC3993705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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