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Article

Detection of multidrug resistance in Mycobacterium tuberculosis.

Journal of clinical microbiology - 1 Jan 2007

Sekiguchi Jun-ichiro, Miyoshi-Akiyama Tohru, Augustynowicz-Kopeć Ewa, Zwolska Zofia, Kirikae Fumiko, Toyota Emiko, Kobayashi Intetsu, Morita Koji, Kudo Koichiro, Kato Seiya, Kuratsuji Tadatoshi, Mori Toru, Kirikae Teruo

Abstract excerpt

We developed a DNA sequencing-based method to detect mutations in the genome of drug-resistant Mycobacterium tuberculosis. Drug resistance in M. tuberculosis is caused by mutations in restricted regions of the genome. Eight genome regions associated with drug resistance, including rpoB for rifampin (RIF), katG and the mabA (fabG1)-inhA promoter for isoniazid (INH), embB for ethambutol (EMB), pncA for pyrazinamide...

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Identifiers

PMID: 17108078
DOI: 10.1128/JCM.00750-06
PMCID: PMC1828975

Genes

EMB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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