Article
Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics.
mAbs - 1 Jan 2018
Piche-Nicholas Nicole M, Avery Lindsay B, King Amy C, Kavosi Mania, Wang Mengmeng, O'Hara Denise M, Tchistiakova Lioudmila, Katragadda Madan
Abstract excerpt
A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG. We have observed that PK of IgG molecules vary widely, even when they share identical Fc domains. This led us to hypothesize that domains distal from the Fc could contribute to FcRn binding and affect PK. In this study, we explored the role of...
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