Article
Single-nucleotide polymorphisms influence the promoter activities of systemic lupus erythematosus-associated genes.
Biotechnology letters - 1 Oct 2020
Qiu Jinjun, Qin Xiaoming, Wen Jinli, Wu Li, Kong Lei, Ou Yangxi, Yang Shucai
Abstract excerpt
Systemic lupus erythematosus (SLE) is a protypical autoimmune disease and genetic factors play important roles in its pathogenesis. Since present SLE susceptibility loci are mainly studied through meta-analysis of genome-wide association study, we performed promoter activity analysis to examine the biological functions of SLE-associated single-nucleotide polymorphisms (SNPs). We found at SNP positions rs1341239,...
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