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Article

A novel c.-274C>G polymorphism in bovine SIRT1 gene contributes to diminished promoter activity and is associated with increased body size.

Animal genetics - 1 Aug 2013

Li Ming-xun, Sun Xiao-mei, Zhang Liang-zhi, Wang Jing, Huang Yong-zhen, Sun Yu-jia, Hu Shen-rong, Lan Xian-yong, Lei Chu-zhao, Chen Hong

Abstract excerpt

SIRT1, a mammalian homologue for yeast silent information regulator 2 (SIR2), is a NAD(+) -dependent deacetylase that belongs to the class III histone deacetylases. It plays an important role in diverse cellular processes, including stress resistance, mitochondrial function, suppression of inflammation and DNA repair. In this study, we screened and identified a novel polymorphism (c.-274C>G) in the SIRT1 promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23647079
DOI: 10.1111/age.12048

Genes

SIRT1

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