Article
Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain.
Biophysical journal - 16 Nov 2011
Rodnin Mykola V, Kyrychenko Alexander, Kienker Paul, Sharma Onkar, Vargas-Uribe Mauricio, Collier R John, Finkelstein Alan, Ladokhin Alexey S
Abstract excerpt
The translocation (T) domain plays a key role in the action of diphtheria toxin and is responsible for transferring the N-terminus-attached catalytic domain across the endosomal membrane into the cytosol in response to acidification. The T-domain undergoes a series of pH-triggered conformational changes that take place in solution and on the membrane interface, and ultimately result in transbilayer insertion and...
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