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Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B.

Toxins - 19 Aug 2020

Pons Benoît J, Loiseau Nicolas, Hashim Saleha, Tadrist Soraya, Mirey Gladys, Vignard Julien

Abstract excerpt

The Cytolethal Distending Toxin (CDT) is produced by many Gram-negative pathogenic bacteria responsible for major foodborne diseases worldwide. CDT induces DNA damage and cell cycle arrest in host-cells, eventually leading to senescence or apoptosis. According to structural and sequence comparison, the catalytic subunit CdtB is suggested to possess both nuclease and phosphatase activities, carried by a single...

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PMID: 32825080
DOI: 10.3390/toxins12090530
PMCID: PMC7551728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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