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Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile

19 Aug 2010

Abstract excerpt

Hypervirulent strains of Clostridium difficile have emerged over the past decade, increasing the morbidity and mortality of patients infected by this opportunistic pathogen. Recent work suggested the major C. difficile virulence factor, TcdB, from hypervirulent strains (TcdB(HV)) was more cytotoxic in vitro than TcdB from historical strains (TcdB(HIST)). The current study investigated the in vivo impact of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20808849
DOI: 10.1371/journal.ppat.1001061

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