TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing.

doi:10.1111/j.1365-2958.2012.08009.x

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Article

TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing.

Molecular microbiology - 1 Apr 2012

Lanis Jordi M, Hightower Logan D, Shen Aimee, Ballard Jimmy D

Abstract excerpt

TcdB, an intracellular bacterial toxin that inactivates small GTPases, is a major Clostridium difficile virulence factor. Recent studies have found that TcdB produced by emerging/hypervirulent strains of C. difficile is more potent than TcdB from historical strains, and in the current work, studies were performed to investigate the underlying mechanisms for this change in TcdB toxicity. Using a series of...

Topics

Bacterial Proteins
Bacterial Toxins
Clostridioides difficile
Phenotype
Phytic Acid
Protein Transport
Proteolysis
Virulence Factors

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Identifiers

PMID: 22372854
DOI: 10.1111/j.1365-2958.2012.08009.x
PMCID: PMC3313004

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