Article
SPOP mutations in prostate cancer across demographically diverse patient cohorts.
Neoplasia (New York, N.Y.) - 1 Jan 2014
Blattner Mirjam, Lee Daniel J, O'Reilly Catherine, Park Kyung, MacDonald Theresa Y, Khani Francesca, Turner Kevin R, Chiu Ya-Lin, Wild Peter J, Dolgalev Igor, Heguy Adriana, Sboner Andrea, Ramazangolu Sinan, Hieronymus Haley, Sawyers Charles, Tewari Ashutosh K, Moch Holger, Yoon Ghil Suk, Known Yong Chul, Andrén Ove, Fall Katja, Demichelis Francecsa, Mosquera Juan Miguel, Robinson Brian D, Barbieri Christopher E, Rubin Mark A
Abstract excerpt
BACKGROUND: Recurrent mutations in the Speckle-Type POZ Protein (SPOP) gene occur in up to 15% of prostate cancers. However, the frequency and features of cancers with these mutations across different populations is unknown. OBJECTIVE: To investigate SPOP mutations across diverse cohorts and validate a series of assays employing high-resolution melting (HRM) analysis and Sanger sequencing for mutational analysis...
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