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Prognostic and Predictive Role of SPOP Mutations in Prostate Cancer: A Systematic Review and Meta-analysis.

European urology oncology - 1 Dec 2024

Pedrani Martino, Salfi Giuseppe, Merler Sara, Testi Irene, Cani Massimiliano, Turco Fabio, Trevisi Elena, Tortola Luigi, Treglia Giorgio, Di Tanna Gian Luca, Vogl Ursula, Gillessen Silke, Theurillat Jean-Philippe, Pereira Mestre Ricardo

Abstract excerpt

CONTEXT: Mutations in the speckle-type POZ (SPOP) gene are frequently identified in prostate cancer (PC); yet, prognostic implications for affected patients remain unclear. Limited consensus exists regarding tailored treatments for SPOP-mutant (SPOPmut) PC. OBJECTIVE: To elucidate the prognostic and predictive significance of SPOP mutations across distinct PC stages and treatments. EVIDENCE ACQUISITION: A...

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PMID: 38704358
DOI: 10.1016/j.euo.2024.04.011

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