Article
SPOP and CHD1 alterations in prostate cancer: Relationship with PTEN loss, tumor grade, perineural infiltration, and PSA recurrence.
The Prostate - 1 Dec 2021
Hernández-Llodrà Silvia, Segalés Laura, Juanpere Nuria, Marta Lorenzo Tech, Salido Marta, Nonell Lara, David López Tech, Rodríguez-Vida Alejo, Bellmunt Joaquim, Fumadó Lluís, Cecchini Lluís, Lloreta-Trull Josep
Abstract excerpt
BACKGROUND: In the non-ETS fusion of prostate cancer (PCa) pathway, SPOP mutations emerge as a distinct oncogenic driver subclass. Both SPOP downregulation and mutation can lead to SPOP target stabilization promoting dysregulation of key regulatory pathways. CHD1 gene is commonly deleted in PCa. CHD1 loss significantly co-occurs with SPOP mutations, resulting in a PCa subclass with increased AR transcriptional...
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