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Clinical and genomic features of SPOP‐mutant prostate cancer

15 Nov 2021

Abstract excerpt

BACKGROUND: Inactivating missense mutations in the SPOP gene, encoding speckle-type poxvirus and zinc-finger protein, are one of the most common genetic alterations in prostate cancer. METHODS: We retrospectively identified 72 consecutive prostate cancer patients with somatic SPOP mutations, through next-generation sequencing analysis, who were treated at the Johns Hopkins Hospital. We evaluated clinical and...

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PMID: 34783071
DOI: 10.1002/pros.24269

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