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Article

Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer

24 Jul 2018

Abstract excerpt

Purpose Molecular characterization of prostate cancer, including The Cancer Genome Atlas, has revealed distinct subtypes with underlying genomic alterations. One of these core subtypes, SPOP (speckle-type POZ protein) mutant prostate cancer, has previously only been identifiable via DNA sequencing, which has made the impact on prognosis and routinely used risk stratification parameters unclear. Methods We have...

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PMID: 30761387
DOI: 10.1200/po.18.00036

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