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Article

Inherited determinants of early recurrent somatic mutations in prostate cancer.

Nature communications - 29 Jun 2017

Romanel Alessandro, Garritano Sonia, Stringa Blerta, Blattner Mirjam, Dalfovo Davide, Chakravarty Dimple, Soong David, Cotter Kellie A, Petris Gianluca, Dhingra Priyanka, Gasperini Paola, Cereseto Anna, Elemento Olivier, Sboner Andrea, Khurana Ekta, Inga Alberto, Rubin Mark A, Demichelis Francesca

Abstract excerpt

Prostate cancer is a highly heritable molecularly and clinically heterogeneous disease. To discover germline events involved in prostate cancer predisposition, we develop a computational approach to nominate heritable facilitators of somatic genomic events in the context of the androgen receptor signaling. Here, we use a ranking score and benign prostate transcriptomes to identify a non-coding polymorphic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28663546
DOI: 10.1038/s41467-017-00046-0
PMCID: PMC5491529

Genes

SPOP
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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