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Article

Prognostic value of the SPOP mutant genomic subclass in prostate cancer.

Urologic oncology - 1 May 2020

Shoag Jonathan, Liu Deli, Ma Xiaoyue, Oromendia Clara, Christos Paul, Ballman Karla, Angulo Cynthia, Cai Peter Y, Gaffney Christopher, Klein Eric, Karnes Jeffrey, Den Robert B, Liu Yang, Davicioni Elai, Barbieri Christopher E

Abstract excerpt

BACKGROUND: Speckle-type POZ protein (SPOP) mutation defines one of the dominant prostate cancer genomic subtypes, yet the impact of this mutation on clinical prognosis is unknown. METHODS: We defined SPOP mutation status either by DNA sequencing or by transcriptional signature in a pooled retrospective multi-institutional cohort, the Decipher retrospective cohort, the Decipher Genomics Resource Information...

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Cohort Studies
Genomics
Mutation
Nuclear Proteins
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatic Neoplasms

Repressor Proteins

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PMID: 32192889
DOI: 10.1016/j.urolonc.2020.02.011

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