Article
Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema.
Thorax - 1 May 2014
Castaldi Peter J, Dy Jennifer, Ross James, Chang Yale, Washko George R, Curran-Everett Douglas, Williams Andre, Lynch David A, Make Barry J, Crapo James D, Bowler Russ P, Regan Elizabeth A, Hokanson John E, Kinney Greg L, Han Meilan K, Soler Xavier, Ramsdell Joseph W, Barr R Graham, Foreman Marilyn, van Beek Edwin, Casaburi Richard, Criner Gerald J, Lutz Sharon M, Rennard Steven I, Santorico Stephanie, Sciurba Frank C, DeMeo Dawn L, Hersh Craig P, Silverman Edwin K, Cho Michael H
Abstract excerpt
BACKGROUND: There is notable heterogeneity in the clinical presentation of patients with COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by applying cluster analysis to data from the COPDGene study. METHODS: We applied a clustering method, k-means, to data from 10 192 smokers in the COPDGene study. After splitting the sample into a training and validation set, we evaluated...
Topics
- Cluster Analysis
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged