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Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene

25 Mar 2019

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1 antitrypsin deficiency and cutis laxa, caused by rare genetic variants. Over the past decade, the proliferation of genome-wide association studies, the accessibility...

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PMID: 30908940
DOI: 10.1164/rccm.201808-1455so

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