Article
Genetic variations in colorectal cancer risk and clinical outcome.
World journal of gastroenterology - 21 Apr 2014
Zhang Kejin, Civan Jesse, Mukherjee Sushmita, Patel Fenil, Yang Hushan
Abstract excerpt
Colorectal cancer (CRC) has an apparent hereditary component, as evidenced by the well-characterized genetic syndromes and family history associated with the increased risk of this disease. However, in a large fraction of CRC cases, no known genetic syndrome or family history can be identified, suggesting the presence of "missing heritability" in CRC etiology. The genome-wide association study (GWAS) platform has...
Topics
- Cell Cycle
- Colorectal Neoplasms
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Polymorphism, Single Nucleotide
- Prognosis
- Risk Factors
- Signal Transduction