Article
Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Aug 2017
Graff Rebecca E, Möller Sören, Passarelli Michael N, Witte John S, Skytthe Axel, Christensen Kaare, Tan Qihua, Adami Hans-Olov, Czene Kamila, Harris Jennifer R, Pukkala Eero, Kaprio Jaakko, Giovannucci Edward L, Mucci Lorelei A, Hjelmborg Jacob B
Abstract excerpt
BACKGROUND & AIMS: We analyzed data from twins to determine how much the familial risk of colorectal cancer can be attributed to genetic factors vs environment. We also examined whether heritability is distinct for colon vs rectal cancer, given evidence of distinct etiologies. METHODS: Our data set included 39,990 monozygotic and 61,443 same-sex dizygotic twins from the Nordic Twin Study of Cancer. We compared...
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