Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes

Abstract excerpt

An important subset of colorectal cancer (CRC) is caused by rare pathogenic variants in more than 20 high-risk genes,1–3 The National Comprehensive Cancer Network clinical practice guidelines (2022) recommend that physicians consider multigene panel testing for these high-risk genes in all newly diagnosed CRC patients2,3 to identify carriers of pathogenic variants and promote testing of family members who may...

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