Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts.

Molecular oncology - 1 May 2014

Topp Monique D, Hartley Lynne, Cook Michele, Heong Valerie, Boehm Emma, McShane Lauren, Pyman Jan, McNally Orla, Ananda Sumitra, Harrell Marisol, Etemadmoghadam Dariush, Galletta Laura, Alsop Kathryn, Mitchell Gillian, Fox Stephen B, Kerr Jeffrey B, Hutt Karla J, Kaufmann Scott H, Australian Ovarian Cancer Study, Swisher Elizabeth M, Bowtell David D, Wakefield Matthew J, Scott Clare L

Abstract excerpt

INTRODUCTION: Improvement in the ability to target underlying drivers and vulnerabilities of high-grade serous ovarian cancer (HG-SOC) requires the development of molecularly annotated pre-clinical models reflective of clinical responses. METHODS: We generated patient-derived xenografts (PDXs) fr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to DNA Methylation

Share to Mice, SCID

Share to Ovarian Neoplasms

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 24560445
DOI: 10.1016/j.molonc.2014.01.008
PMCID: PMC4400120

Genes

BRCA1
BCL2
BRCA2
CCNE1
LIN28B
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24560445-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts.PMID 24560445Read ↗

A Genomically Characterized Collection of High-Grade Serous Ovarian Cancer Xenografts for Preclinical Testing.Semantic proximity Read ↗

A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.Semantic proximity Read ↗

Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer.Semantic proximity Read ↗

Comprehensive Genomic Characterization in Ovarian Low-Grade and Chemosensitive and Chemoresistant High-Grade Serous Carcinomas.Semantic proximity Read ↗

Longitudinal Prediction of Drug Response in High-Grade Serous Ovarian Cancer Organoid Cultures Aligning with Clinical ResponsesSemantic proximity Read ↗

Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivorsSemantic proximity Read ↗

Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.Semantic proximity Read ↗

Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.Semantic proximity Read ↗

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinomaSemantic proximity Read ↗

Establishment and characterization of a platinum- and paclitaxel-resistant high grade serous ovarian carcinoma cell line.Semantic proximity Read ↗

The Changing View of High-Grade Serous Ovarian CancerSemantic proximity Read ↗

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.