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Article

A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.

JCI insight - 12 Jan 2017

George Erin, Kim Hyoung, Krepler Clemens, Wenz Brandon, Makvandi Mehran, Tanyi Janos L, Brown Eric, Zhang Rugang, Brafford Patricia, Jean Stephanie, Mach Robert H, Lu Yiling, Mills Gordon B, Herlyn Meenhard, Morgan Mark, Zhang Xiaochen, Soslow Robert, Drapkin Ronny, Johnson Neil, Zheng Ying, Cotsarelis George, Nathanson Katherine L, Simpkins Fiona

Abstract excerpt

Approximately 50% of high-grade serous ovarian cancers (HGSOCs) have defects in genes involved in homologous recombination (HR) (i.e., BRCA1/2). Preclinical models to optimize therapeutic strategies for HR-deficient (HRD) HGSOC are lacking. We developed a preclinical platform for HRD HGSOCs that includes primary tumor cultures, patient-derived xenografts (PDXs), and molecular imaging. Models were characterized by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28097235
DOI: 10.1172/jci.insight.89760
PMCID: PMC5214535

Genes

ATR
BRCA1
PARP1

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