Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer.

doi:10.1002/cam4.3831

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Article

Tumor genomic, transcriptomic, and immune profiling characterizes differential response to first-line platinum chemotherapy in high grade serous ovarian cancer.

Cancer medicine - 1 May 2021

Weberpals Johanne I, Pugh Trevor J, Marco-Casanova Paola, Goss Glenwood D, Andrews Wright Natalie, Rath Prisni, Torchia Jonathon, Fortuna Alexander, Jones Gemma N, Roudier Martine P, Bernard Laurence, Lo Bryan, Torti Dax, Leon Alberto, Marsh Kayla, Hodgson Darren, Duciaume Marc, Howat William J, Lukashchuk Natalia, Lazic Stanley E, Whelan Doreen, Sekhon Harmanjatinder S

Abstract excerpt

BACKGROUND: In high grade serous ovarian cancer (HGSOC), there is a spectrum of sensitivity to first line platinum-based chemotherapy. This study molecularly characterizes HGSOC patients from two distinct groups of chemotherapy responders (good vs. poor). METHODS: Following primary debulking surgery and intravenous carboplatin/paclitaxel, women with stage III-IV HGSOC were grouped by response. Patients in the...

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Identifiers

PMID: 33811746
DOI: 10.1002/cam4.3831
PMCID: PMC8085970

Genes

PARP4
ATR
BRCA2
EMSY
MECOM
MGA
PIK3CA
RAD51B

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