Alpelisib enhances cisplatin mediated cytotoxicity in non-mutated, PIK3CA-dependent high-grade serous ovarian cancer.

doi:10.1186/s13048-026-02171-1

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Article

Alpelisib enhances cisplatin mediated cytotoxicity in non-mutated, PIK3CA-dependent high-grade serous ovarian cancer.

Journal of ovarian research - 23 Jun 2026

Mehrotra Megha, Chakraborty Sourav, Saldanha Elveera, Joshi Diksha, Dhadve Ajit, Sakpal Asmita, Chandrani Pratik, Maheshwari Amita, Menon Santosh, Ghosh Jaya, Gupta Sudeep, Ray Pritha

Abstract excerpt

BACKGROUND: High-Grade Serous Ovarian Cancer (HGSOC) has a dismal five-year survival rate (< 30%) owing to late detection and recurrence caused by platinum resistance. Targeted therapy exhibits efficacy only within a limited patient population, warranting the need to identify new therapeutic regimes. Herein, we investigated the efficacy of a PIK3CA inhibitor, alpelisib, combined with cisplatin using malignant...

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Topics

Female
Humans
Cisplatin
Class I Phosphatidylinositol 3-Kinases
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Mice

Cell Line, Tumor

Cystadenocarcinoma, Serous

Xenograft Model Antitumor Assays

Mutation

Apoptosis

Tumor Suppressor Protein p53

Neoplasm Grading

Antineoplastic Agents

Thiazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 42332790
DOI: 10.1186/s13048-026-02171-1
PMCID: PMC13543539

Genes

PIK3CA
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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