Article
Double suppression of the Gα protein activity by RGS proteins.
Molecular cell - 20 Feb 2014
Lin Chen, Koval Alexey, Tishchenko Svetlana, Gabdulkhakov Azat, Tin Uliana, Solis Gonzalo P, Katanaev Vladimir L
Abstract excerpt
Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis on G protein α subunits, restricting their activity downstream from G protein-coupled receptors. Here we identify Drosophila Double hit (Dhit) as a dual RGS regulator of Gαo. In addition to the conventional GTPase-activating action, Dhit possesses the guanine nucleotide dissociation inhibitor (GDI) activity, slowing the rate of GTP uptake...
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