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Article

Small-molecule inhibitor of Gαo for GNAO1 encephalopathy.

Bioscience reports - 20 May 2026

Larasati Yonika A, Koval Alexey, Katanaev Vladimir L

Abstract excerpt

GNAO1-related neurodevelopmental disorders are caused by mutations in the GNAO1 gene encoding the major neuronal G protein, Gαo. GNAO1 encephalopathies manifest in a range of symptoms, including epilepsy, movement disorder, hypotonia, and developmental delay, affecting >400 patients worldwide to date. A growth in the number of diagnosed cases is expected due to the wider availability of whole genome sequencing....

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Identifiers

PMID: 42024408
DOI: 10.1042/BSR20250392
PMCID: PMC13185127

Genes

GNAO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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