Article
Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer.
Molecular pharmacology - 17 Oct 2024
Dwyer Morgan B, Aumiller Jenna L, Wedegaertner Philip B
Abstract excerpt
G protein-coupled receptors (GPCRs) couple to heterotrimeric G proteins, comprised of α and βγ subunits, to convert extracellular signals into activation of intracellular signaling pathways. Canonically, GPCR-mediated activation results in the exchange of GDP for GTP on G protein α subunits (Gα) and the dissociation of Gα-GTP and G protein βγ subunits (Gβγ), both of which can regulate a variety of signaling...
Topics
- Humans
- Neoplasms
- Mutation
- Signal Transduction
- GTP-Binding Protein alpha Subunits
- Animals
- Receptors, G-Protein-Coupled