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Article

HOX deregulation in acute myeloid leukemia

2 Apr 2007

Abstract excerpt

The deregulation of homeobox (HOX) genes in acute myeloid leukemia (AML) and the potential for these master regulators to perturb normal hematopoiesis is well established. To date, overexpression of HOX genes in AML has been attributed to specific chromosomal aberrations and abnormalities involving mixed-lineage leukemia (MLL), an upstream regulator of HOX genes. The finding reported in this issue of the JCI by...

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PMID: 17404613
DOI: 10.1172/jci31861

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