<i>HOX</i>and<i>Non‐HOX</i>Homeobox Genes in Leukemic Hematopoiesis

Abstract excerpt

Dysregulation of homeobox (HB)-containing genes is becoming increasingly recognized as the underlying basis of many hematologic malignancies. Expression of clustered HB (HOX) genes within the hematopoietic system, and enforced overexpression and knockout studies have provided support for the concept that these homeodomain-containing transcription factors play a significant role in the developmental biology of...

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