Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer.

doi:10.1186/bcr2635

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Article

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer.

Breast cancer research : BCR - 1 Jan 2010

Prat Aleix, Parker Joel S, Karginova Olga, Fan Cheng, Livasy Chad, Herschkowitz Jason I, He Xiaping, Perou Charles M

Abstract excerpt

INTRODUCTION: In breast cancer, gene expression analyses have defined five tumor subtypes (luminal A, luminal B, HER2-enriched, basal-like and claudin-low), each of which has unique biologic and prognostic features. Here, we comprehensively characterize the recently identified claudin-low tumor subtype. METHODS: The clinical, pathological and biological features of claudin-low tumors were compared to the other...

Topics

Animals
Biomarkers, Tumor
Breast Neoplasms
Carcinoma, Ductal, Breast
Cell Line, Tumor
Claudins
Epithelial-Mesenchymal Transition
ErbB Receptors
Female
Gene Expression
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Neoplastic Stem Cells

Phenotype

Prognosis

Receptors, Estrogen

Receptors, Progesterone

Source

Open in PubMed Open full text

Identifiers

PMID: 20813035
DOI: 10.1186/bcr2635
PMCID: PMC3096954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20813035-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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