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RB1 and p53 at the crossroad of EMT and triple-negative breast cancer

15 May 2011

Abstract excerpt

Triple-negative breast cancer (TNBC) is a heterogeneous disease that includes Basal-like and Claudin-low tumors. The Claudin-low tumors are enriched for features associated with epithelial-to-mesenchymal transition (EMT) and possibly for tumor initiating cells. Primary TNBCs respond relatively well to conventional chemotherapy; however, metastatic disease is virtually incurable. Thus, there is a great interest in...

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PMID: 21502814
DOI: 10.4161/cc.10.10.15703

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