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Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

1 Jun 2011

Abstract excerpt

The claudin-low subtype is a recently identified rare molecular subtype of human breast cancer that expresses low levels of tight and adherens junction genes and shows high expression of epithelial-to-mesenchymal transition (EMT) genes. These tumors are enriched in gene expression signatures derived from human tumor-initiating cells (TICs) and human mammary stem cells. Through cross-species analysis, we...

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PMID: 21633010
DOI: 10.1073/pnas.1018862108

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