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Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer

18 Mar 2013

Abstract excerpt

Triple-negative breast cancer (TNBC) accounts for ∼20% of cases and contributes to basal and claudin-low molecular subclasses of the disease. TNBCs have poor prognosis, display frequent mutations in tumor suppressor gene p53 (TP53), and lack targeted therapies. The MET receptor tyrosine kinase is elevated in TNBC and transgenic Met models (Met(mt)) develop basal-like tumors. To investigate collaborating events in...

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PMID: 23509284
DOI: 10.1073/pnas.1210353110

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