Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

4 Apr 2013

Abstract excerpt

Wnt signaling in mouse mammary development and tumorigenesis has been heavily studied and characterized, but its role in human breast cancer remains elusive. Although Wnt inhibitors are in early clinical development, it is unclear whether they will be of therapeutic benefit to breast cancer patients, and subsequently, to which ones. To address this, we generated a panel of Wnt reporting human breast cancer cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to RNA Research and Splicing
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23559372
DOI: 10.1073/pnas.1303671110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paracrine Wnt signaling both promotes and inhibits human breast tumor growthPMID 23559372Read ↗

Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating CellsSemantic proximity Read ↗

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cellsSemantic proximity Read ↗

The Wnt Signalling Pathway: A Tailored Target in CancerSemantic proximity Read ↗

Targeting Met and Notch in the<i>Lfng</i>-deficient,<i>Met</i>-amplified triple-negative breast cancerSemantic proximity Read ↗

Wnt signaling in cancer: from biomarkers to targeted therapies and clinical translationSemantic proximity Read ↗

Wnt Signaling in the Breast: From Development to DiseaseSemantic proximity Read ↗

An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast CancerSemantic proximity Read ↗

Wnt signaling in cancer.Semantic proximity Read ↗

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.Semantic proximity Read ↗

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic MiceSemantic proximity Read ↗

Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in miceSemantic proximity Read ↗

Wnt signaling in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.