Article
Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.
The Journal of biological chemistry - 23 Apr 2010
Wang Hongbo, Mo Pingli, Ren Shumei, Yan Chunhong
Abstract excerpt
Genomic integration of human papillomavirus (HPV) DNA accounts for more than 90% of cervical cancers. High-risk genital HPVs encode E6 proteins that can interact with a cellular ubiquitin ligase E6-associated protein (E6AP) and target the tumor suppressor p53 for ubiquitin-mediated proteolysis. Currently, how this critical event is regulated is largely unknown. Here we report that activating transcription factor...
Topics
- Activating Transcription Factor 3
- Alphapapillomavirus
- Apoptosis
- Cell Cycle
- Cell Line
- Cell Transformation, Viral
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation
- Oncogene Proteins, Viral