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Article

Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.

The Journal of biological chemistry - 1 May 2015

Ji Lei, Xu Jinjin, Liu Jian, Amjad Ali, Zhang Kun, Liu Qingwu, Zhou Lei, Xiao Jianru, Li Xiaotao

Abstract excerpt

Specific p53 mutations abrogate tumor-suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort TGF-β signaling, which paradoxically displays both tumor-suppressive and pro-oncogenic functions. The molecular mechanisms of how mutant p53 simultaneously antagonizes the tumor-suppressive and synergizes the tumor-promoting function of the TGF-β pathway remain...

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Identifiers

PMID: 25767119
DOI: 10.1074/jbc.M115.639351
PMCID: PMC4416873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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