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Article

Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of function.

The Journal of biological chemistry - 7 May 2010

Gurtner Aymone, Starace Giuseppe, Norelli Giuseppe, Piaggio Giulia, Sacchi Ada, Bossi Gianluca

Abstract excerpt

Mitogen-activated protein kinase kinase 3 (MAP2K3) is a member of the dual specificity kinase group. Growing evidence links MAP2K3 to invasion and tumor progression. Here, we identify MAP2K3 as a transcriptional target of endogenous gain-of-function p53 mutants R273H, R175H, and R280K. We show that MAP2K3 modulation occurred at the mRNA and protein levels and that endogenous mutant p53 proteins are capable of...

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Identifiers

PMID: 20223820
DOI: 10.1074/jbc.M109.094813
PMCID: PMC2863202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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