Article
Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice.
Oncogene - 4 Jan 2018
Wang Z, He Y, Deng W, Lang L, Yang H, Jin B, Kolhe R, Ding H-F, Zhang J, Hai T, Yan C
Abstract excerpt
Mice lacking genes involving in the DNA-damage response (DDR) are often tumor prone owing to genome instability caused by oncogenic challenges. Previous studies demonstrate that activating transcription factor 3 (ATF3), a common stress sensor, can activate the tumor suppressor p53 and regulate expression of p53 target genes upon DNA damage. However, whether ATF3 contributes to the maintenance of genome stability...
Topics
- Activating Transcription Factor 3
- Animals
- Apoptosis
- Carcinogenesis
- Cell Line, Tumor
- Chromosome Aberrations
- DNA Damage
- Female
- Fibroblasts
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease